THE ANTIBACTERIAL EFFECT OF SOME MEDICINAL PLANTS (INULA VISCOSA, ANACYCLUS VALENTINUS) AND THEIR SYNERGISTIC INTERACTION WITH ANTIBIOTIC DRUGS

Authors

  • K. Side Larbi Bioconversion Research Labortory, Engineering Microbiology and Health Safety, Faculty of SNV, University of Mascara, Algeria
  • B. Meddah 2Laboratory of glucides- Team Thera.- FRE-CNRS 3517, Faculty of Pharmacy, University of Picardie, Amiens
  • A. Tir Touil Meddah Bioconversion Research Laboratory, Engineering Microbiology and Health Safety, Faculty of SNV, University of Mascara
  • P. Sonnet Laboratory of glucides- Team Thera.- FRE-CNRS 3517, Faculty of Pharmacy, University of Picardie, Amiens

DOI:

https://doi.org/10.4314/jfas.v8i2.5

Keywords:

antibiotic resistant, Inula viscosa, Anacyclus valentinus, synergy

Abstract

With the emergence of multidrug-resistant organisms, combining medicinal plants with synthetic medicines against resistant bacteria becomes necessary. In this study, Synergism between plant extracts (methanolic extract and essential oils of Inula viscosa and Anacyclus valentinus) and two commonly used antibiotics (gentamycin, oxacillin) were investigated on three bacterian strains (E. coli, Bacillus subtilis, Staphylococcus aureus). In the first time, the antibacterial effect of extracts alone was tested against 7 strains by disc diffusion and microdilution methods. The minimum inhibitory concentrations of methanolic extracts ranged between 6.25 and 50mg/ml while that of the essential oils varied between 12.5 and 100µL/mL. Interactions extracts /antibiotics and extracts/extracts by checkboard. The results show that the synergistic effect of combinations plant extracts/antibiotics was more important than extracts/extracts.

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Published

2016-05-01

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Section

Research Articles